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Preventive measures focus on maintaining nasal moisture and avoiding trauma
24 Large molecular size and structural complexity make biologics highly susceptible to degradation by gastric acid and digestive enzymes, leading to loss of activity before absorption can occur
Lilly noted a portion of those were for "perceived excessive weight loss" rather than tolerability patients with lower baseline BMIs were losing weight faster than they wanted
Diabetes 47:621631 Noda M, Yamashita S, Takahashi N et al (2002) Switch to anaerobic glucose metabolism with NADH accumulation in the beta-cell model of mitochondrial diabetes
Oral Treatment of Obesity by GLP-1 and Its Analogs Holler et al
